Biochemical characterization of variants of canine CYP1A1 using heterologous expression

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Biochemical characterization of variants of canine CYP1A1 using heterologous expression

Cytochrome P450 1A1 (CYP1A1) is a heme-containing mono-oxygenase involved in metabolism of environmental contaminants. Two variants of dog CYP1A1 with a single residue difference were identified and designated Sap1 and Sap2. Compared with Sap1, Sap2 had a Trp50Leu substitution. The biochemical characteristics of the variants were comparatively analyzed using heterologous expression in Escherich...

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ژورنال

عنوان ژورنال: Journal of Veterinary Medical Science

سال: 2017

ISSN: 0916-7250,1347-7439

DOI: 10.1292/jvms.17-0192